Presynaptic plasticity lab

The PrePlast lab investigates the molecular mechanisms of presynaptic function and dysfunction.

Release of neurotransmitter from the presynapse initiates signal transmission between neurons and is therefore of fundamental importance for neuronal communication. This process is based on sequence of membrane trafficking events that are tightly regulated in time and space and assisted by dynamic interactions of multitude of proteins and lipids. Our research focuses on investigation of the molecular machinery involved in the neurotransmitter release at mammalian brain synapses and its regulation in physiological conditions and in diseased brain. We aim for better understanding of this process, which is necessary to identify the key entry points for its regulations and in long terms for development of meaningful therapeutic approaches.

Presynaptic cytomatrix at the active zone organises spatially and funcitonally  the cycling of neurotransmitter-filled synaptic vesicles