New paper online.

Dani’s study about regulation of synaptic vesicle recycling at excitatory synapses by Amyloid beta and alpha7 nicotinic acetylcholine receptors is online.

AĪ²1-16 controls synaptic vesicle pools at excitatory synapses via cholinergic modulation of synapsin phosphorylation

Congratulations Dani and thanks to the whole team!

We discussed this topic extensively at our symposium at the 14th meeting of German neuroscience society in the symposium S26  Regulation of synaptic vesicle recycling: from physiology to disease.

What a day!

Yesterday, after the work, we took our backpacks and climbed over the hill to look over town of Erlangen. Then we spent nice evening in the beer-garden in Atzelsberg.


Today Daniela defended her thesis. Congratulations, Dani! You did a great job!

Daniela explaining her work.
Under the mask there is a wide smile šŸ˜ƒ!

New paper

Zoicas et all described new mouse model of depression where acid sphyngomyelinase (Smpd1) was overexpressed exclusively in the forebrain. Thanks for nice collaboration Iulia and Cosima!

New paper is online

Our work on the role of CtBP1 in retrieval of synaptic vesicles is online.

Ivanova etĀ al. demonstrate a dual role of CtBP1 in synaptic transmission. Nuclear CtBP1 restricts synaptogenesis and vesicular release probability, whereas presynaptic CtBP1 promotes compensatory endocytosis via activation of the lipid enzyme PLD1. Phosphorylation by Pak1 controls the redistribution of CtBP1 from active zones toward endocytic sites linking presynaptic exo- and endocytosis.

Bye, bye 2019: It was a great year!

I neglected updating the website over last months. It was really busy year and here are only few lab events to share now. Better late than never!

Lab Outing at the Christmas Market in Erlangen; December 2019

New paper online!

New paper of our collaborators Martin Heine and David Holcman aboutĀ splice variants of Cav2.1, theirĀ molelcualr dynamics and effect onĀ neurotransmissionĀ is just published in Neuron. Congratulations Martin and David, well done! Thanks, that we could contributeĀ to this nice study!

Heck et al., 2019

Presynaptic CaV2.1 channels are confined in nanodomains, for which size and dwell time are modulated by network activity. Heck etĀ al. show that changing the affinity to scaffold proteins by alternative splicing of CaV2.1 directly affects short-term plasticity.