Our work on the role of CtBP1 in retrieval of synaptic vesicles is online.
Ivanova et al. demonstrate a dual role of CtBP1 in synaptic transmission. Nuclear CtBP1 restricts synaptogenesis and vesicular release probability, whereas presynaptic CtBP1 promotes compensatory endocytosis via activation of the lipid enzyme PLD1. Phosphorylation by Pak1 controls the redistribution of CtBP1 from active zones toward endocytic sites linking presynaptic exo- and endocytosis.
New paper of our collaborators Martin Heine and David Holcman about splice variants of Cav2.1, their molelcualr dynamics and effect on neurotransmission is just published in Neuron. Congratulations Martin and David, well done! Thanks, that we could contribute to this nice study!
Presynaptic CaV2.1 channels are confined in nanodomains, for which size and dwell time are modulated by network activity. Heck et al. show that changing the affinity to scaffold proteins by alternative splicing of CaV2.1 directly affects short-term plasticity.