Aneta’s work was published in Journal of Neurochemistry providing the cover image.

Debarpan published his data on Developmental effect of RASopathy-linked PTPN11 mutation on synaptic vesicle fusion competence in Cellular and Molecular Neurobiology. Read the full text here.

Fewer synaptic vesicles fuse in response to electrical stimulation in cortical neurons expressing a PTPN11^D61Y RASopathy mutation.

Congratulations and thank you and all the team for your efforts!

Our new study on the rapid effects of hydroxynorketamine, a metabolite of the fast-acting antidepressant ketamine, on presynaptic neurotransmitter release was published in Translational Psychiatry.

Congratulations Debarpan and all!

Click here to read.

Eva-Maria just posted her new MEA study on developmental effects of RASopathies on establishment and maturation of neuronal networks on bioRxiv.

The study is now published here.

Developmental effect of RASopathy mutations on neuronal network activity on a chip

We are proud to announce that EURAS project was funded in frame of European Union’s “Horizon Europe” research and innovation programme.

EURAS connects 16 partners form 8 European countries that will join forces to develop new effective therapies and operative disease management for neurodevelopmental RASopathies.

Read more

EURAS is coordinated form our institution and funded under grant agreement
No. 101080580.

The presynaptic protein bassoon organizes synaptic vesicles into functional pools at glutamatergic synapses via regulation of presynaptic phosphorylation and cAMP homeostasis. This study further reveals that a CDK5/PDE4/cAMP axis controls neurotransmitter release.

New paper is online

https://www.embopress.org/doi/full/10.15252/embr.202153659

Burcu joined lab several weeks ago to work on the role of CtBP1 in neurodevelopment.

This Monday, Lena defended her thesis. Well done, Lena! Congratulations and all the best for all your future projects!

We are pleased to announce a release of nice study led by our collaborator Prof. Christian Müller. It was pleasure to contribute, thanks Christian!

Neutral sphingomyelinase mediates the co-morbidity trias of alcohol abuse, major depression and bone defects

On Monday, Debarpan defended his PhD. Congratulations. You did a great job and we are delighted to have you in the team!