New paper of our collaborators Martin Heine and David Holcman about splice variants of Cav2.1, their molelcualr dynamics and effect on neurotransmission is just published in Neuron. Congratulations Martin and David, well done! Thanks, that we could contribute to this nice study!
Presynaptic CaV2.1 channels are confined in nanodomains, for which size and dwell time are modulated by network activity. Heck et al. show that changing the affinity to scaffold proteins by alternative splicing of CaV2.1 directly affects short-term plasticity.