New paper online.

Our study about regulation of synaptic vesicle recycling at excitatory synapses by Amyloid beta and alpha7 nicotinic acetylcholine receptors is online.

Anni et al., (2021) demonstrated that Aβ1-42 and Aβ1-16, but not Aβ17-42, increased size of the recycling pool of synaptic vesicles (SV). This presynaptic effect was driven by enhancement of endogenous cholinergic signalling via α7 nicotinic acetylcholine receptors, which led to activation of calcineurin, dephosphorylation of synapsin 1 and consequently resulted in reorganization of functional pools of SV increasing their availability for sustained neurotransmission. These results identify synapsin 1 as a molecular target of Aβ and reveal an effect of physiological concentrations of Aβ on cholinergic modulation of glutamatergic neurotransmission.

Congratulations Dani and thanks to the whole team!

We discussed this topic extensively at our symposium at the 14th meeting of German neuroscience society in the symposium S26  Regulation of synaptic vesicle recycling: from physiology to disease.

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